The Eagles' Week 4 matchup against the Rams has been significantly impacted by injuries, with Philadelphia missing key players DeVonta Smith and Zack Baun, while Los Angeles will be without Aaron Donald but expects Puka Nacua to return. The absence of Smith, who is sidelined with a hamstring injury, leaves the Eagles without four starters, prompting a larger role for Darius Cooper and increased opportunities for Makai Lemon.

Cooper is anticipated to step in for Smith, having previously made a notable contribution with two catches for 26 yards and a game-winning touchdown against the Titans. Meanwhile, Lemon, who has had a modest season thus far, is expected to see more vertical passes as he works on the outside, potentially capitalizing on his impressive separation metrics among rookies.

On the Rams' side, Donald's absence is a significant blow to their defense, while Nacua's return could bolster their offense. Both teams are adjusting to these changes, relying on lesser-used players to step up, making this game a critical test of depth for both squads.